| 1 | Nate’s Theme | Greg Edmonson | 1:45 |
| 2 | Grave Robbing | Greg Edmonson | 2:01 |
| 3 | Sir Francis Drake | Greg Edmonson | 1:07 |
| 4 | The Search for el Dorado | Greg Edmonson | 2:50 |
| 5 | Uncharted Island | Greg Edmonson | 3:08 |
| 6 | Plane-wrecked | Greg Edmonson | 2:56 |
| 7 | The Fortress | Greg Edmonson | 2:02 |
| 8 | Unlocking the Past | Greg Edmonson | 3:35 |
| 9 | Drowned City | Greg Edmonson | 2:11 |
| 10 | Trapped | Greg Edmonson | 4:23 |
| 11 | Heading Upriver | Greg Edmonson | 2:36 |
| 12 | Sanctuary? | Greg Edmonson | 4:24 |
| 13 | Treasure Vault | Greg Edmonson | 3:24 |
| 14 | A Bitter End | Greg Edmonson | 1:11 |
| 15 | Unwelcome Guests | Greg Edmonson | 4:48 |
| 16 | The Bunker | Greg Edmonson | 4:36 |
| 17 | Drake’s Elegy | Greg Edmonson | 1:56 |
| 18 | El Goddamn Dorado | Greg Edmonson | 3:06 |
| 19 | Showdown | Greg Edmonson | 2:26 |
| 20 | Uncharted Theme | Greg Edmonson | 1:52 |
| 21 | Uncharted: The Eldorado Megamix | DJ Shadow | 4:17 |